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VIAGRA [Sildenafil citrate] An Overview
VIAGRA [Sildenafil citrate] is the only approved and effective oral agent for the treatment of erectile dysfunction. Before that a few lines on erectile dysfunction. Erectile dysfunction [Impotence] is a condition in which erection the penis cannot be achieved during sexual intercourse/masturbation. There are many causes for erectile dysfunction. The most common cause of being increasing age. Other conditions can be: - Diabetes Mellitus - Hypertension - Heart Disease - Atherosclerosis - Lower spinal cord injury - Cancer prostate - Psychogenic - Stress Erection is achieved when there is increased blood flow to penis and hence the main organic cause is disturbance of blood flow to and from the penis. Coming back to VIAGRA [Sildenafil citrate], Viagra is a selective and potent inhibitor of cyclic guanosine monophosphate [cGMP] specific phosphodiesterase type 5 inhibitor [PDE5] which is the predominant phosphodiesterase isoform found in the penis. It is administered in doses of 25, 50 and 100 mg, and enhances erection after sexual stimulation. The onset of action is around 60-90 mins. Sildenafil (compound UK-92,480) was synthesized by a group of chemists working at Pfizer's Sandwich, Kent research facility in England. It was initially studied for use in hypertension and angina pectoris. The first clinical trials were conducted in Morriston Hospital in Swansea. Phase I clinical trials under the direction of Ian Osterloh suggested that the drug had little effect on angina, but that it could induce marked penile erections. VIAGRA [Sildenafil citrate] was approved for use in erectile dysfunction by the Food and Drug Administration on March 27, 1998, becoming the first pill approved to treat erectile dysfunction Reduced initial doses should be considered for patients, who are elderly, have renal insufficiency, or are taking medications that inhibit the CYP3A4 metabolic pathway in the liver [e.g., erythromycin, cimetidine, ketoconazole] as they may increase the serum concentration of sildenafil. The drug does not affect ejaculation, orgasm or sexual drive. When sexual stimulation causes local release of NO, inhibition of PDE5 by VIAGRA [Sildenafil citrate] causes increased levels of cGMP in the corpus cavernosum of the penis resulting in smooth muscle relaxation and inflow of blood to the corpus cavernosum. Side Effects: ?? Headaches ?? Facial flushing ?? ringing in ears, or sudden hearing loss ?? Dyspepsia ?? Nasal congestion. ?? Abnormal vision [blue halo effect] ?? Diarrhea ?? Dizziness ?? Rashes Viagra can decrease blood flow to the optic nerve of the eye, causing sudden vision loss:- Special precautions: In patients with ?? Bleeding disorders such as hemophilia ?? Liver disorder ?? Kidney disorder ?? Active peptic ulcerations and ?? Anatomical deformation of the penis, such as peyronie's disease. ?? Retinitis pigmentosa Contraindications: VIAGRA [Sildenafil citrate], is contraindicated in men receiving nitrate therapy for cardiovascular disease, including agents delivered by oral, sublingual, trans-nasal or topical routes. These agents can potentates its hypotensive effect and may result in profound shock. Viagra should be avoided in patients with congestive heart failure and cardiomyopathy because of the risk of vascular collapse.
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Natural Male Enhancements
Many people with impotence problems may have wondered about effective ways to deal with erectile dysfunction. Apart from drugs such as Viagra which are expensive there are herbal drugs which are available. They are manufactured from natural herbs such as Ginseng, Horny Goat Weed, Cnidium, Bombyx Mori, Schizandra berries and other herbs. These "herbal viagra" tablets are as effective as any other... 
Realpharmacyrx offers the best prices you've found anywhere for Viagra. We offer fast discreet shipping and online prescription consultations. We believe that our online store represent the best all around choice for people looking for a reputable online source of the drug.Generic Viagra are cost-effective substitutes for brand names.Viagra, sildenafil citrate,is the first oral drug for Erectile...
A contented sexual life promises an easy-going and lovable relationship between the partners. Erectile dysfunction (ED) is a problem associated with men and they confront a limp penis at the time of sex, which deprives them from enjoying sex with their partner. Though, it was thought that ED is mainly addressed to the older generation, but research shows that it is a common problem with the male...
Erectile dysfunction is a state of men wherein they lack the ability to sustain erection that is needed during intercourse. Thus, the people who have this kind of sexual problem would like to find the safe and best erectile dysfunction medicine available.
There can be various causes for this kind of ailment and it can be physical, mental, or emotional problems that led to erectile dysfunction....
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